Isaac Kohane, Ph.D. (HMS, Biomedical Informatics) directs the newly formed Department of Biomedical Informatics at HMS. This Department is based on the foundational principle that in the decades ahead, the state of an individual will be characterized with increasing precision from the molecular level to genomic parameters to the organ level and for interactions with medications, nutrients, the microbiome, therapeutic devices, and the environment. It is achieving an integrated view of the individual’s current (diagnosis) and future (prognosis) state that has been the focus of his methodological and engineering efforts.