Mary-Elizabeth Patti is an established physician/scientist focused on integrative approaches to the study of diabetes risk, with laboratory investigation using both human samples and animal models to identify novel mechanisms mediating risk for obesity and type 2 diabetes. Her research expertise includes studies of the influence of the early life environment on diabetes risk, epigenetic contributions to intergenerational progression of risk, insulin/IGF1 action, bioenergetic analysis of oxidative metabolic function in cells and isolated mitochondria, and stem cell isolation and analysis. She has developed substantial expertise in both technical aspects of genomics analysis and integrative data analysis of both transcriptomic and metabolomics data linked to diabetes risk in humans and mice, and currently serves as co-director of the Joslin Diabetes Research Center (DRC) Molecular Phenotyping and Genotyping Core Laboratory and director of the DRC Enrichment Core.